Mitochondrial dysfunction has a substantial influence on amino acid metabolism in cachectic skeletal muscles
Kunzke, T. et al. (2019). Derangements of amino acids in cachectic skeletal muscle are caused by mitochondrial dysfunction. J Cachexia Sarcopenia Muscle, doi: 10.1002/jcsm.12498 .
Cachexia is a major cause for cancer-associated deaths. This study investigates the amino acid metabolism in cachectic muscles with in situ-omics techniques. Concentrations of amino acids, proteins, as well as energy and other cellular metabolites are determined and analyzed with MALDI mass spectrometry imaging.