A new multimodal procedure combining MALDI imaging with imaging microscopy for improved therapy prediction.
Huber, K. et al. (2019). Multimodal analysis of formalin-fixed and paraffin-embedded tissue by MALDI imaging and fluorescence in situ hybridization for combined genetic and metabolic analysis, Laboratory Investigation, doi: 10.1038/s41374-019-0268-z.
The study presents a multimodal approach for the identication of genetic and metabolic properties from one tissue section. Combined with clinical data, including survival and response, this combined workflow is a promising tool for biomarker research, prognostics, and to improve response prediction.