Imaging analysis can unravel the novel role of D-serine in regulating systemic glucose metabolism through modulating insulin secretion

Suwandhi, L. et al. (2018). Chronic d-serine supplementation impairs insulin secretion, Molecular Metabolism, doi: 10.1016/j.molmet.2018.07.002.

Mass spectrometry is suitable for the visualization of metabolically important neurotransmitters in tissues and can be used in studies that include the evaluation of imbalances in neurotransmitter levels.

Pulmonary fibrosis: Investigating the metabolic processes of the antifibrotic agent pirfenidone.

Sun N et al. (2018). Pharmacometabolic response to pirfenidone in pulmonary fibrosis detected by MALDI-FTICR-MSI, European Respiratory Journal, DOI:10.1183/13993003.02314-2017.

The combination of pharmacological and metabolomic methods ultimately led to an improved understanding of the disease mechanisms of idiopathic pulmonary fibrosis, as well as the mechanisms of action of pirfenidone.

Theratype is supported by the Helmholtz Association and Helmholtz Zentrum München

The spin-off project Theratype was granted by the Helmholtz Association and Helmholtz Zentrum München. Read more about it on the research center’s own press information and news page.

PAXgene, an alcohol-based tissue fixative, enables comprehensive molecular tissues analysis

Urban, C. et al. (2017). PAXgene fixation enables comprehensive metabolomic and proteomic analyses of tissue specimens by MALDI MSI, Biochimica et Biophysica Acta, DOI:10.1016/j.bbagen.2017.10.005.

An alcohol-based non-crosslinking tissue fixative, PAXgene Tissue System, has been successful tested as an alternative fixative to formalin for multi-omic tissue analysis.