Suwandhi, L. et al. (2018). Chronic d-serine supplementation impairs insulin secretion, Molecular Metabolism, doi: 10.1016/j.molmet.2018.07.002.
Mass spectrometry is suitable for the visualization of metabolically important neurotransmitters in tissues and can be used in studies that include the evaluation of imbalances in neurotransmitter levels.
Sun N et al. (2018). Pharmacometabolic response to pirfenidone in pulmonary fibrosis detected by MALDI-FTICR-MSI, European Respiratory Journal, DOI:10.1183/13993003.02314-2017.
The combination of pharmacological and metabolomic methods ultimately led to an improved understanding of the disease mechanisms of idiopathic pulmonary fibrosis, as well as the mechanisms of action of pirfenidone.
The spin-off project Theratype was granted by the Helmholtz Association and Helmholtz Zentrum München. Read more about it on the research center’s own press information and news page.
Urban, C. et al. (2017). PAXgene fixation enables comprehensive metabolomic and proteomic analyses of tissue specimens by MALDI MSI, Biochimica et Biophysica Acta, DOI:10.1016/j.bbagen.2017.10.005.
An alcohol-based non-crosslinking tissue fixative, PAXgene Tissue System, has been successful tested as an alternative fixative to formalin for multi-omic tissue analysis.