First analytical proof for in situ imaging of metabolites from formalin‐fixed, paraffin‐embedded (FFPE) human tissue samples
Buck, A. & Ly, A. et al. (2015). High-resolution MALDI-FT-ICR MS Imaging for the analysis of metabolites from formalin-fixed paraffin-embedded clinical tissue samples, The Journal of Pathology, doi:10.1002/path.4560
Clinical tissue samples are commonly conserved as formalin‐fixed, paraffin‐embedded (FFPE) patient samples and can be archived for many years. In this study, MALDI-FT-ICR mass spectrometry imaging was used to analyse the metabolite landscape in FFPE tissues. The localization of different metabolites were demonstrated and used to answer tumour biology and clinical questions.